Taking into account previous research that suggests Oxt is able to offer some protection against excessive alcohol consumption, through its actions on the Oxtr (Bahi et al., 2016; King et al., 2017; Schuckit & Hesselbrock, 1994), and female vulnerability to alcohol abuse (Anker & Carroll, 2011), we sought to investigate how genetic disruption of the Oxtr affected stress‐induced alcohol consumption in female and male Oxtr knockout (−/−) mice. This evidence concerns the gene OXTR and alcohol abuse.