Nevertheless, the tumours in the four remaining patients (cases 4, 12, 21, and 23) were considered to represent bona fide MPNSTs on the following evidence: all had an NF‐1 clinical phenotype; the tumour from case 12 arose from a large nerve and exhibited a low‐grade component; and cases 21 and 23 contained a low‐grade component, while case 4 revealed heterozygous alterations of core genes of PRC2. The gene discussed is NF1; the disease is neoplasm.