NF1 and malignant peripheral nerve sheath tumor: In summary, loss of H3K27me3 expression was observed in 50% (n = 16) of NF‐1‐associated MPNSTs, 25% (n = 20) of sporadic MPNSTs, and in the single radiation‐associated MPNST (case 35, Table 3), with an overall loss of H3K27me3 in 38% (14/37) of sequenced MPNSTs, including two grade 1 cases.