It will also be interesting to examine whether POST1 affects autoprocessing of proprotein convertase subtilisin kexin 9 (PCSK9), which is classified as non-basic proprotein convertases along with S1P and, importantly, serves as an emerging drug target for hyperlipidemia and cardiovascular disease (Burke et al., 2017). This evidence concerns the gene PCSK9 and hyperlipidemia.