The common (5% or higher) severe AEs were decreased white blood cell count (11% and 16%), neutropenia (15% and 32%), anemia (21% and 24%), and anorexia (1.6% and 11%) in the UGT1A1 WT and UGT1A1 SH groups. This evidence concerns the gene UGT1A1 and Decreased total neutrophil count.