In studies of these LGR‐null models, LGR5‐KO mice are nonviable and die within 24 hours after parturition, but present with a neonatal cleft palate‐like phenotype, suggesting LGR5 is involved in craniofacial development.(53) LGR6‐KO mice appear to develop normally with no apparent or overt skeletal phenotype.(1, 7). The gene discussed is LGR5; the disease is cleft palate.