One of the reasons for the increase in NF-κB levels in melanoma cells can be over-expression of toll like receptor 4 by melanoma cells.7 Toll-like receptors (TLRs), like other pattern recognition receptors, are responsible for recognizing different molecular patterns for example molecular patterns of pathogens.8 It has been shown that TLR4 is overexpressed in different cancers. The gene discussed is NFKB1; the disease is melanoma.