Yun et al reported that BACH1 is a let-7-regulated transcription factor which induces the expression of matrix metalloproteinases 1 (MMP1) in favor of tumor progression.19 Moreover, Liang et al demonstrated that BACH1 knockdown resulted in significant suppression of metastasis, and conversely, ectopic expression of BACH1 was significantly linked to the malignancy of breast cancer cells. The gene discussed is BACH1; the disease is neoplasm.