Centrally-acting drugs that inhibit acetylcholinesterase and thus reduce acetylcholine degradation can be a suitable way to control AD progression.11 So, a selective therapeutic option is to increase the level of acetylcholine by using cholinesterase inhibitors such as donepezil (Don) which reduces synaptic acetylcholine degradation and enhances the normal pattern of acetylcholine release in the brain.12 Drugs like Don and galantamine are able to activate the cholinergic anti-inflammatory pathway.9 Here, ACHE is linked to Alzheimer disease.