The Stat3/ NF-κB signaling pathway is activated by secreted cytokines such as IL-1β, IL-6 and IL-8 and modification in a positive way leads to CSCs stemness preservation, neovascularization and metastasis.57,58 Molecular modification of the tumor microenvironment can block the growth of CSCs. Here, CXCL8 is linked to neoplasm.