The origin of breast CSCs is the mammary multipotent stem cells with genetic defects that affect pathways related to self-renewal and differentiation.15 So, the origin of these cells is important for the prevention, early detection, and breast cancer therapy.16 CSCs have the similarities with normal stem cells like being quiescent, multipotency and self-renewal capacity that these specifications helps preserve the tumor.17 CD44+/CD24low/- and ALDH are common CSC markers that are the same with normal stem cells. The gene discussed is CD44; the disease is breast carcinoma.