Repertaxin as an inhibitor of IL-8 increase chemotherapy efficiency and diminishing tumor size.59 Here also combinatorial therapy makes the curing process more effective than before multiple biological approaches by using IL-6 and IL-8 inhibitors or HIF pathway blocking.60 It seems there is more detail information about signaling pathways needed to overcome CSCs microenvironment suitability. The gene discussed is IL6; the disease is neoplasm.