The other factors such as CEA (P < 0.001), tumor length (P < 0.001), tumor circumferential extent (P < 0.001), clinical T category (P < 0.001), the neoadjuvant regimen (P = 0.007), and the distance from the anal verge (P = 0.031) were considered significant predictors for good response (Table 2). Here, CEACAM5 is linked to neoplasm.