CD4 and systemic lupus erythematosus: As indicated from the results, circ_0012919 reduction enriched the expression of DNMT1, decreased the expressions of CD70 and CD11a, and reversed the DNA hypomethylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematosus (SLE); however, it was reversible by DNMT1 reduction [51].