CASP8 and ovarian cancer: Although there is no study in the literature regarding the effect of Pxd on mRNA expression levels of CASP3, CASP8 and CASP9 genes HCT-116p53+/+ and HCT-116p53-/- cells, active caspase-8, caspase-9 and caspase-3 activities were increased by inducing Fas-dependent apoptotic pathway of 24 hours of Pxd administration in various ovarian cancer cells have been shown to increase (Kamsteeg et al., 2003[21]).