Furthermore, when corresponding to 5-Fu and/or 1-OHP co-administration, Pxd pre-treatment followed by 5-Fu and/or 1-OHP administration to both CRC cells increased the mRNA expression levels of CASP3 and CASP9 and, these elevations were statistically important (P<0.05). The gene discussed is CASP9; the disease is colorectal carcinoma.