CASP9 and ovarian cancer: In addition, another in vitro study, showing the change in apoptotic markers observed at different time intervals after treatment of CP70 ovarian cancer cell line with 10 μg/mL Pxd, showed the degradation of proapoptotic Bak protein at 16 hours post-treatment, significant increase in caspase-8, caspase-9 and caspase-3 activity and the presence of p30 XIAP (Alvero et al., 2006[5]).