Statistically significant increase in the amount of the cleaved caspase-3 protein was detected for administrations of 5-Fu and/or 1-OHP co-administration, and Pxd pre-treatment followed by 5-Fu and/or 1-OHP in both CRC cells (p<0.05) (Figure 3A-B(Fig. 3)). This evidence concerns the gene CASP3 and colorectal carcinoma.