BRCA1 and breast carcinoma: Pathogenic variants in BRCA1 and BRCA2 are associated with high risk of developing breast and ovarian cancers.1,2 A recent study of BRCA1/2 carriers estimated the average risk of developing breast cancer by age 80 years to be 72% for BRCA1 and 69% for BRCA2 carriers.2 Corresponding ovarian cancer risks were 44% for BRCA1 and 17% for BRCA2 carriers.