NFKB1 and infectious disease: More interesting, enriched pathway analysis revealed that the down-regulated proteins of HaCaT cells were highly associated with pathways that can be mainly related to the anti-inflammatory effect of LAB, such as: neutrophil degranulation, immune system, infectious disease, interleukin-1 signalling, cytokine signalling in immune system, and signalling by interleukins; as well as NF-kB, Hedgehog, and RUNX-related pathways (Table 2).