CD4 and infection: We curated (Supplementary Table 1) 46 CPSF6(+) RIGs from multiple cell types (HEK293T, HOS, MDM, and CD4+ T cells) and 30 CPSF6(−) RIGs from these same cells when infection occurred in the absence of the CA–CPSF6 interaction (i.e., N74D or A77V CA mutant viruses, or WT CA infection of CKO cells).