GLS and hepatocellular carcinoma: Besides, it was reported that expression level of CFIm25 in hepatocellular carcinoma (HCC) was negatively correlated to the metastatic potential of HCC cell line through increasing E-cadherin level31, while glutaminase mRNA isoforms, which contain distinct 3′-UTR (KGA and GAC), showed a complex interplay between RNA processing and microRNA repression in controlling glutamine metabolism in cancer cells14.