As has been reported in gastrointestinal cancers, tumor cell-derived exosomal miRNAs mediate crosstalk between tumor cells and the stromal microenvironment, and induce polarization of the macrophages to the anti-inflammatory and tumor-supportive M2 state via activation of the PTEN-PI3K signaling cascade under hypoxic conditions resulting in enhanced metastatic capacity24,25. The gene discussed is PTEN; the disease is neoplasm.