AKT1 and neoplasm: Likewise, the hijacking of CAFs to support EMT in the context of diminished immune surveillance in the epithelial-stromal spatial domain42,59,60 (Figs. 5 and 6) and the PI3K/AKT-mediated polarization of TAMs within the stromal domain (Figs. 5 and 6) can conspire to facilitate migration of tumor initiating cells to promote both local and distant recurrence61.