Furthermore, we analyzed single-cell RNA sequencing data (scRNAseq) from patient biopsies in multiple cancer-types (OVCA, melanoma, head and neck squamous cell carcinoma, HNSCC), and found that IL10 signaling may occur at especially high levels in myeloid cells including TAMs expressing both IL10 and its receptor components IL10RA (Fig. 9a) and IL10RB (see “Methods”). This evidence concerns the gene IL10RB and head and neck squamous cell carcinoma.