In vitro, aIL10R blocked the effects of IL4-MΦ on MT coherence and orientation, as reflected by a shift in the PC describing the two features (Fig. 9d, calculated as in Fig. 5a; Supplementary Fig. 17), and also reversed the effects of IL4-MΦ on tumor cell circularity (Fig. 9e). The gene discussed is IL4; the disease is neoplasm.