Interestingly, Prdm2-null mice develop diffuse large B-cell lymphomas (DLBCL)20, while its overexpression induces p53-dependent apoptosis21; (iii) The PRDM14 locus (8q13) is amplified in nearly 25% of human lymphoid neoplasms22,23; (iv) Last, to date there is no evidence that PRDM15 has any functional role in tumorigenesis, despite its documented overexpression in follicular lymphoma (FL)24. Here, PRDM2 is linked to diffuse large B-cell lymphoma.