The most efficient PRDM15-specific AON (IC50 = 25 nM) (Supplementary Fig. 2A and B) induced the skipping of exon 15 (Fig. 1d),subsequently reducing PRDM15 protein levels (Fig. 1e) in a primary patient-derived relapsed DLBCL. This evidence concerns the gene PRDM15 and diffuse large B-cell lymphoma.