Acute depletion of PRDM15 by addition of 4-OHT to cell culture media (Fig. 3c) resulted in a severe growth delay of the lymphoma cells, which was rescued by exogenous expression of PRDM15 in the Prdm15Δ/Δ cells, confirming that this phenotype is caused by PRDM15 loss (Fig. 3d). The gene discussed is PRDM15; the disease is lymphoma.