The vast majority of these TFs were found to be expressed in AML samples (198 had higher expression than TBP), and many of them are involved in haematopoietic gene regulation and/or in the aetiology of AML, including SPI1, TAL1, IKZF1 and PKNOX1 (Fig. 3a). Here, SPI1 is linked to acute myeloid leukemia.