Heterozygous deletion of another LTR5B element, bound by BCOR, SPI1, TAL1 and RUNX1 (Fig. 4a, middle), reduced the expression of Ribosomal Protein L7 Like 1 (RPL7L1) (Fig. 4c, left), which is upregulated in AML when compared with differentiated myeloid cells (Fig. 4c, right). The gene discussed is RUNX1; the disease is acute myeloid leukemia.