ACE2 and COVID-19: For example, debate is ongoing about whether patients taking ACE inhibitors should be advised to switch drug class owing to their association with increased ACE2 expression.14–16 Conversely, medications that downregulate ACE2 expression may be of interest as part of a strategy to reduce viral transmission.17 While recent studies have discussed the evidence surrounding ACE inhibitors and angiotensin receptor blockers in the context of COVID-19,18 the evidence for the effects of a broader range of drugs remains unclear.