Although Zhao SJ et al. [34] reported that SPARCL1 was downregulated in OS by epigenetic methylation of promoter DNA, and that SPARCL1 could suppress osteosarcoma metastasis and recruit macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT-receptor complex, this study, on the contrary, noticed that SPARCL1 continued to be upregulated during osteosarcoma development and metastasis. The gene discussed is SPARCL1; the disease is osteosarcoma.