For instance, by conducting bioinformatics analysis on three datasets deposited in GEO database (GSE36001, GSE19276 and GSE16088), Pan Liu et al. [10] revealed that tumor protein p53 (TP53), mitogen-activated protein kinase 1 (MAPK1), estrogen receptor 1 (ESR1), notch homolog protein 3 (NOTCH3) and caspase 1 (CASP1) might potentially be important osteosarcoma-associated genes. This evidence concerns the gene NOTCH3 and osteosarcoma.