We first used RNA sequencing analysis from CAF subsets isolated from BC (data deposited at the European Genome-phenome Archive under accession number EGAS00001002508) [22] and found that CDH11 (cadherin 11, also referred to as osteoblast cadherin) was significantly up-regulated in CAF-S1 subset compared to the other CAF subsets (Fig. 4a). This evidence concerns the gene CDH11 and breast cancer.