Importantly, using multivariate analyses by the Cox proportional hazard model, we observed that distant recurrence in early luminal BC was associated with the CAF-S1 subset (HR = 5.02; CI95% [2.34–10.73]; p < 0.0001), independent of any other features analyzed, such as CDH1 H score, ROR risk category, CD4+ T lymphocyte infiltration, and macrophage infiltration and vascularization (Table 2). This evidence concerns the gene CD4 and breast cancer.