EIF2AK3 and Alzheimer disease: A study by Wiersma et al., 2019, used in-vitro and and in-vivo tau seeding models to show that the development of tau pathology induces the formation of granulovacuolar degeneration bodies (GVBs) which contain p-PERK and p-eIF2α, similar to what is seen in the human AD hippocampus [49].