Thus, the treatment of these cells with serum of JIA patients induced the expression of inflammatory cytokines and chemokines, and significantly elevated the expression of adipokines, such as leptin, visfatin and resistin, compared to the treatment with the serum from healthy donors, resembling to what was observed in vivo in patients (Fig. 4g, h). The gene discussed is RETN; the disease is juvenile idiopathic arthritis.