In our study of 585 patients with CHD, we identified two rare heterozygous mutations of FGF8, namely p.C10Y and p.R184H, in two unrelated patients both affected with TOF, and one deletion of FGF10, namely p.23_24del, in a patient with single atrium, single ventricle, complete atrioventricular canal defect, pulmonary stenosis, and pulmonary hypertension. Here, FGF8 is linked to coronary artery disorder.