ACE2 and COVID-19: Indeed, prompted by the evidence that male sex predisposes to severe COVID-19 and by the fact that male sex hormones impact on the ACE-2 pathway which facilitates the entry of SARS-CoV-2 into host cells [8, 28–30], Goren et al. documented that significant androgenic alopecia was a common feature (71%) in a small cohort of hospitalized male COVID-19 patients [n, 41; mean age (range), 58 (23–79) years] [31].