SHBG and polycystic ovary syndrome: Of note, a male PCOS equivalent syndrome has been proposed, which is characterized by early-onset androgenic alopecia in combination with one or more manifestations such as worse gonadal steroidogenesis, decreased sex hormone binding globulin (SHBG), and increased dehydroepiandrosterone sulphate (DHEAS) circulating levels, as well as insulin resistance, T2DM, obesity, and hypertension [36, 37].