Significance levels were also calculated for thyroid dysfunction (Begg = 0.029 and Egger’s = 0.001), hypothyroidism (Begg = 0.003 and Egger’s = 0.004), clinical hypothyroidism (Begg = 0.029 and Egger’s = 0.001), subclinical hypothyroidism (Begg = 0.058 and Egger’s = 0.010), hyperthyroidism (Begg = 0.533 and Egger’s = 0.002), clinical hyperthyroidism (Begg = 0.999 and Egger’s = 0.269), subclinical hyperthyroidism (Begg = 0.763 and Egger’s = 0.026), and anti-TPO Ab (Begg = 0.710 and Egger’s = 0.368). This evidence concerns the gene TPO and hyperthyroidism.