ALK and non-small cell lung carcinoma: Camidge et al. screened 1426 NSCLC clinical specimens (174 ALK rearranged and 1252 ALK not rearranged) and found an increased native ALK copy number (≥3 copies/cell in ≥40% cells) in 19% of ALK rearranged cells and 62% of ALK non-rearranged cells [16].