Clinical evidence shows that the methylation state of CpG sites of zinc finger protein 267 (ZNF267), actin binding LIM protein family member 2 (ABLIM2), Ras homolog family member J (RHOJ), and cyclin dependent kinase like 5 (CDKL5) genes is correlated with postmenopausal osteoporosis [42]. Here, CDKL5 is linked to postmenopausal osteoporosis.