However, the pathologies associated with AD include the presence of amyloid plaques comprised of amyloid-β (Aβ) aggregates [3,4,5,6,7,8,9,10], neurofibrillary tangles resulting from the intra-neuronal accumulation of hyperphosphorylated tau protein [11], and neuroinflammation that causes gliosis and further exacerbates Aβ production [12,13,14,15]. Here, MAPT is linked to Alzheimer disease.