Concerning the role of the renin–angiotensin system in the development and rupture of aortic aneurysms, reducing AngII with angiotensin-converting enzyme (ACE) inhibitors was found to be beneficial in limiting aneurysm progression, independently of its role as an antihypertensive drug, since other antihypertensive drugs could not lower the risk of aneurysm rupture [19]. This evidence concerns the gene REN and aneurysm.