In human aortic samples obtained during surgical repair following aortic dissection, STAT3 activation was associated with neutrophil infiltration and in a mouse model of acute aortic dissection, the CXCL1 (chemokine (C-X-C motif) ligand 1)/granulocyte-colony stimulating factor pathway was highlighted in the recruitment of neutrophils. Here, CXCL1 is linked to Aortic dissection.