APOE and aortic aneurysm: While AngII infusion in ApoE−/− is known to trigger aortic aneurysm formation as well as aortic dissection due to concomitant vascular wall remodeling and recruitment of monocytes and macrophages, we did not find differences between aortas from LRP8+/+ and LRP8−/− mice concerning histology or expression of prominent genes involved in vascular inflammation or remodeling [16].