CHROME knockdown in human macrophages increases the levels of miR-27b, miR-33a, miR-33b, and miR-128, thereby reducing the expressions of their overlapping target gene networks, including ABCA1. Since CHROME is also expressed in hepatocytes, it can play an important role in systemic cholesterol homeostasis in atherosclerosis [85]. Here, CHROMR is linked to atherosclerosis.