It is possible that the systemic inflammatory state caused by hepatitis induces the expansion of peripheral Bregs; beside that, HCC itself may produce abundant specific cytokines and chemoattractant including IL-8 [37] and CCL 20 [38], some of which are responsible for the “homecoming” signals which orient regulatory lymphocytes into the tumor. This evidence concerns the gene CXCL8 and hepatocellular carcinoma.