Bregs may suppress the antitumor immunity and promote HCC progression via several mechanisms including the CD40/CD40L signaling-mediated cytokine production of IL10, TGF-β which downregulates TNF- α, PD-1hi B-cell, Granzyme B-secreting B cells (GrB+ B cells), Treg upregulation, TH17 downregulation, and IL-35 which triggers the genesis of Tregs from naive T cells with the subsequent suppression of the anticancer immune response. This evidence concerns the gene IL10 and hepatocellular carcinoma.