According to meta-analyses, RA-associated alleles in Caucasians include –174G/C and –572G/C of the IL6 gene, rs1800896 in the IL10 gene, rs13151961 and rs6822844 located near the IL2 and IL21 genes, rs7530511 and rs11209026 in the IL23R gene, and some others. The gene discussed is IL6; the disease is rheumatoid arthritis.