TNF and rheumatoid arthritis: According to the other meta-analyses, more than 20 SNPs associated with the targeted anti-TNF therapy response in patients with RA could be identified in the genes involved in T-cell functioning, NFκB and TNFα signalling pathways, as well as in CTCN5, TEC, PTPRC, FCGR2A, NFKBIB, FCGR2A, IRAK325, and other genes [85].