STING1 and neoplasm: The increased production of key inflammatory cytokines and chemokines needed for T-cell migration and the upregulation of maturation markers on DCs, together with an increase in the quantity and functional capacity of the tumor-infiltrating CTLs, was notably present in the tumors, showing that the activation of innate immunity through STING activation can potentially reverse the immunosuppressive PDAC TME [156].