Moreover, while characterizing the cell of origin phenotype, CD10, BCL6, and MUM1 play a pivotal role, by driving the GC-type identification, differentiated by CD10 and/or BCL6 expression in >30% of DLBCL cells, while their low expression, along with >30% expression of MUM1 documentation, indicates a non-GC-type [58]. Here, IRF4 is linked to diffuse large B-cell lymphoma.