In more detail, among ABC DLBCLs, the C1 subtype DLBCL was deemed to be associated with favorable prognosis and was characterized by MYDnon-L265P, NOTCH2, and SPEN mutations, as well as BCL6 SVs, and this phenotype might origin from marginal-zone lymphoma and from an ancestor of extrafollicular origin [63]. Here, BCL6 is linked to diffuse large B-cell lymphoma.