Among the other compounds identified in COME, the two coumarins umbelliferone and methoxsalen have been reported to suppress the expression of NF-κB in animal models [62,63], while peonidin-3-glucoside to reduce the metastasis of lung cancer cells by acting via different mechanisms, among which the blocking of AP-1 activation [64]. The gene discussed is NFKB1; the disease is lung carcinoma.