APOE and early-onset autosomal dominant Alzheimer disease: In Alzheimer’s disease (AD), some LDLR genetic variants seem to be associated with disease risk or prevention [58] both because LDLR is a receptor of ApoE, which represents a risk factor of AD depending on the expressed allele, and because LDLR has been shown to regulate the brain-to-blood amyloid-beta clearance [59].