Recently, we reported that ProS1 is the preferred ligand for Tyro3 receptor in human cancer cells that express multiple TAMs, and identified two discrete signalling axes, ProS1-Tyro3-Erk and Gas6-Axl-Akt, that exist side by side in these cells, mediating proliferative and survival signalling, respectively [6]. The gene discussed is AKT1; the disease is cancer.