RPE and familial pancreatic carcinoma: Ribulose 5-Phosphate 3-Epimerase (RPE) has been detected in pancreatic cancer, and its effect might be through the activation of fructose 2,6 bisphosphate (F-2, 6BP), which activates phosphofructose kinase 1 (PFK1), and/or K-ras [67,68,69].