The possibility that SET-NUP214 is related to mitochondria dysregulation is supported by the observation that patients with SET-NUP214 T-related ALL are resistant to glucocorticoid (GC) therapy, which induces a metabolic shift from glycolysis to oxidative phosphorylation (OXPHOS; [20,78]). The gene discussed is NUP214; the disease is acute lymphoblastic leukemia.