INS and Hypoglycemia: For example, Breton et al. [30] proposed a DSS that includes: A CGM-based bolus advisor, which optimally modulates insulin boluses based on an estimate of the patient’s current insulin sensitivity; an exercise advisor, which provides ad-hoc behavioral advice if the risk of hypoglycemia is detected when the patient begins an exercise session; and a retrospective insulin titration tool, based on a personalized simulation model, which periodically revises the therapy parameters if a glycemic risk profile is detected.