In a subset of acute promyelocytic leukemia (APL) patients, as a consequence of the t(5;17)(q35;q31) translocation, the NPM1 N-terminal portion is fused with the DNA-binding domain of RARα (retinoic acid receptor α), altering the transcriptional activity of the latter [57]. Here, RARA is linked to acute promyelocytic leukemia.