Since p14ARF is one of NPM1 interactors that are displaced to the cytoplasm in NPM1-mutated AML [68] and given that p14ARF is often altered in several cancers [117], the NPM1 surface that interacts with p14ARF has been proposed as a target for interfering small molecules to be used in the treatment of AML or possibly other cancers [118]. Here, NPM1 is linked to acute myeloid leukemia.