NPM1 and acute myeloid leukemia: Recently, Gu and collaborators [71] demonstrated that Selinexor treatment of a patient-derived xenograft mouse model of NPM1-mutated AML restored NPM1c+ nuclear localization and induced monocytic/granulocytic terminal differentiation, which was likely disrupted by NPM1c+-induced delocalization of the myeloid transcription factor PU.1 [71].