A more recent translocation, t(5;19)(q35;p13), was observed in lymphoproliferative disorders (LPDs) and consists in the fusion of almost full length NPM1 with the catalytic domain of TYK2 (protein tyrosine kinase 2), whose kinase activity results constitutively activated, in a way similar to what reported for ALK-NPM1. The gene discussed is NPM1; the disease is lymphoproliferative syndrome.