In vitro experiments highlighted that AVA also binds the mutant form of NPM1, with a higher affinity with respect to wild-type, probably due to the unfolded status of NPM1c+ CTD, and partially re-localizes it within the nucleoli of OCI-AML3 cells, a useful model cell line of AML carrying NPM1c+ [128]. Here, RUNX2 is linked to acute myeloid leukemia.