In the past years, NPM1 has been identified as one of the targets of the synthetic pseudopeptide NucAnt N6L (hereby N6L), a pro-apoptotic compound able to exert antiproliferative activity and to inhibit tumor growth also in vivo, that has already completed Phase I/IIa clinical trials for different solid tumors [162,163,164]. The gene discussed is NPM1; the disease is neoplasm.