Studies in animal models have shown that vascular NOX1 expression appears to be important for hypertension, since overexpression of this enzyme was observed in different hypertension models (two-kidney two-clip renovascular hypertensive rats, transgenic hypertensive rats overexpressing the renin 2 gene, angiotensin II-infused mice, and others) [12,13]. Here, NOX1 is linked to Hypertension.