In the present study, we provide experimental evidence that 10-gingerol, a major phytochemical constituent in ginger, can target lipid raft-associated PI3K/Akt signaling through the modulation of lipid rafts, leading to cell death and apoptosis in radio-resistant triple negative breast cancer cells (MDA-MB-231/IR). Here, AKT1 is linked to triple-negative breast carcinoma.