ALDOA and Fulminant hepatitis: Concerning liver expression of hepatotoxicity biomarker genes (Figure 6a), Aldoa (encoding for fructose-bisphosphate aldolase A, a glycolytic enzyme) significantly increased upon tramadol exposure, as previously seen in serum from patients with fulminant hepatitis [187] and drug-induced liver injury [188], as well as in liver tissue from animal models acutely and sub-acutely exposed to different xenobiotics [189,190,191,192].