On the other hand, high-level expression of HMGB1 is evident in the microenvironments of many types of advanced malignancies, originating from tumor cells per se, and from tumor-infiltrating myeloid cells in particular, as well as lymphoid cells [95] and structural cells such as endothelial cells [96] and fibroblasts [97]. The gene discussed is HMGB1; the disease is neoplasm.