With respect to potential mechanisms of angiogenesis involving HMGB1/TAM interactions, Rojas et al., albeit in a series of in vitro experiments, reported that exposure of a gastric adenocarcinoma cell line (MKN45) to a M2 macrophage-like cell line in the presence of HMGB1 resulted in a series of pro-angiogenic events [154]. Here, HMGB1 is linked to gastric adenocarcinoma.