In an earlier study focused on gastric carcinoma, Kuniyasu et al. observed that 7/8 gastric tumor cell lines constitutively expressed RAGE-encoding mRNAs, and that the invasive potential of one of these cell lines (MKN28) was attenuated by treatment with a RAGE-targeted antisense S-oligonucleotide [147]. This evidence concerns the gene AGER and gastric neoplasm.