Alongside ALBI grade, univariable analyses of survival revealed CTP class (p < 0.01), BCLC stage (p = 0.04), AFP > 400 ng/mL (p = 0.02), achievement of radiologic disease control (p < 0.001) and provision of further anti-cancer therapy post-ICI (p < 0.001) as significant prognostic factors for OS. This evidence concerns the gene AFP and cancer.