TANs within papillomas and tumors also shared features related to repressed cytoskeleton reorganization controlling neutrophil functions (cluster 2), repressed leukocyte extravasation and migration (cluster 3), decrease of specific inflammatory and immune responses (cluster 3 and 4), and response to CXCL8 (IL-8) and TGF-β (cluster 6 and 7). The gene discussed is CXCL8; the disease is papilloma.